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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
01/11/2018 |
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Actualizado : |
07/11/2018 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
ZARANTONELLI, L.; SUANES, A.; MENY, P.; BURONI, F.; SALVARREY,X.; BRIANO , C.; ASHFIELD, N.; SILVEIRA, C.S.; DUTRA, F.; EASTON, C.; FRAGA, M.; GIANNITTI, F.; HAMOND, C.; MACÍAS-RIOSECO, M.; MENÉNDEZ, C.; MORTOLA, A.; PICARDEAU, M. |
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Afiliación : |
LETICIA ZARANTONELLI, Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo, Uruguay.; Unidad Mixta UMPI, Institut Pasteur de Montevideo; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay.; ALEJANDRA SUANES, Departamento de Bacteriología, División Laboratorios Veterinarios "Miguel C. Rubino" Sede Central, Ministerio de Ganadería, Agricultura y Pesca, Uruguay.; PAULINA MENY, Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Uruguay.; FLORENCIA BURONI, División Laboratorios Veterinarios "Miguel C. Rubino" Laboratorio Regional Noroeste, Ministerio de Ganadería, Agricultura y Pesca, Uruguay.; XIMENA SALVARREY, Departamento de Bacteriología, División Laboratorios Veterinarios "Miguel C. Rubino". Sede Central, Ministerio de Ganadería, Agricultura y Pesca, Uruguay .; CAROLINA BRIANO, Departamento de Bacteriología, División Laboratorios Veterinarios "Miguel C. Rubino" Sede Central, Ministerio de Ganadería, Agricultura y Pesca, Uruguay .; NATALIA ASHFIELD4, Departamento de Bacteriología y Virologí, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Uruguay.; CAROLINE DA SILVA SILVEIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FERNANDO DUTRA, División Laboratorios Veterinarios "Miguel C. Rubino". Laboratorio Regional Este, Ministerio de Ganadería, Agricultura y Pesca, Uruguay.; CRISTINA EASTON, Departamento de Bacteriología, División Laboratorios Veterinarios "Miguel C. Rubino" Sede Central, Ministerio de Ganadería, Agricultura y Pesca, Uruguay.; MARTIN FRAGA COTELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAMILA HAMOND, Unidad Mixta UMPI, Institut Pasteur de Montevideo ; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MELISSA MACÍAS RIOSECO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CLARA MENÉNDEZ, Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Uruguay.; ALBERTO MORTOLA, Departamento de Bacteriología, División Laboratorios Veterinarios "Miguel C. Rubino" Sede Central, Ministerio de Ganadería, Agricultura y Pesca, Uruguay.; MATHIEU PICARDEAU, Institut Pasteur de Montevideo, Uruguay. / Institut Pasteur, France. |
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Título : |
Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis. |
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Fecha de publicación : |
2018 |
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Fuente / Imprenta : |
PLoS Neglected Tropical Diseases, September 2018, vol. 12, Issue 9, Article number e0006694. OPEN ACCESS. |
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DOI : |
10.1371/journal.pntd.0006694 |
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Idioma : |
Inglés |
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Notas : |
Article History: Received: February 8, 2018; Accepted: July 16, 2018; Published: September 13, 2018. |
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Contenido : |
Abstract:
Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. In South America, and including in Uruguay, beef and dairy export are leading sources of national income. Despite the importance of bovine health, food safety, and bovine-related dissemination of leptospirosis to humans, extremely limited information is available as to the identity of Leptospira species and serovars infecting cattle in Uruguay and the South American subcontinent. Here we report a multicentric 3-year study resulting in the isolation and detailed characterization of 40 strains of Leptospira spp. obtained from infected cattle. Combined serologic and molecular typing identified these isolates as L. interrogans serogroup Pomona serovar Kennewicki (20 strains), L. interrogans serogroup Canicola serovar Canicola (1 strain), L. borgpetersenii serogroup Sejroe serovar Hardjo (10 strains) and L. noguchii (9 strains). The latter showed remarkable phenotypic and genetic variability, belonging to 6 distinct serogroups, including 3 that did not react with a large panel of reference serogrouping antisera. Approximately 20% of cattle sampled in the field were found to be shedding pathogenic Leptospira in their urine, uncovering a threat for public health that is being largely neglected. The two L. interrogans serovars that we isolated from cattle displayed identical genetic signatures to those of human isolates that had previously been obtained from leptospirosis patients. This report of local Leptospira strains shall improve diagnostic tools and the understanding of leptospirosis epidemiology in South America. These strains could also be used as new components within bacterin vaccines to protect against the pathogenic Leptospira strains that are actually circulating, a direct measure to reduce the risk of human leptospirosis.
© 2018 Zarantonelli et al. http://creativecommons.org/licenses/by/4.0/. MenosAbstract:
Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. In South America, and including in Uruguay, beef and dairy export are leading sources of national income. Despite the importance of bovine health, food safety, and bovine-related dissemination of leptospirosis to humans, extremely limited information is available as to the identity of Leptospira species and serovars infecting cattle in Uruguay and the South American subcontinent. Here we report a multicentric 3-year study resulting in the isolation and detailed characterization of 40 strains of Leptospira spp. obtained from infected cattle. Combined serologic and molecular typing identified these isolates as L. interrogans serogroup Pomona serovar Kennewicki (20 strains), L. interrogans serogroup Canicola serovar Canicola (1 strain), L. borgpetersenii serogroup Sejroe serovar Hardjo (10 strains) and L. noguchii (9 strains). The latter showed remarkable phenotypic and genetic variability, belonging to 6 distinct serogroups, including 3 that did not react with a large panel of reference serogrouping antisera. Approximately 20% of cattle sampled in the fi... Presentar Todo |
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Palabras claves : |
SALUD ANIMAL. |
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Thesagro : |
LEPTOSPIRA; LEPTOSPIROSIS. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/11772/1/Zarantonelli-2018-Isolation-of-pathogenic-leptospira-1.pdf
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Marc : |
LEADER 03472naa a2200373 a 4500
001 1059268
005 2018-11-07
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1371/journal.pntd.0006694$2DOI
100 1 $aZARANTONELLI, L.
245 $aIsolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis.
260 $c2018
500 $aArticle History: Received: February 8, 2018; Accepted: July 16, 2018; Published: September 13, 2018.
520 $aAbstract: Leptospirosis is a neglected zoonosis with worldwide distribution. The causative agents are spirochete bacteria of the Leptospira genus, displaying huge diversity of serovars, the identity of which is critical for effective diagnosis and vaccination purposes. Among many other mammalian species, Leptospira infects cattle, eliciting acute signs in calves, and chronic disease in adult animals often leading to abortions. In South America, and including in Uruguay, beef and dairy export are leading sources of national income. Despite the importance of bovine health, food safety, and bovine-related dissemination of leptospirosis to humans, extremely limited information is available as to the identity of Leptospira species and serovars infecting cattle in Uruguay and the South American subcontinent. Here we report a multicentric 3-year study resulting in the isolation and detailed characterization of 40 strains of Leptospira spp. obtained from infected cattle. Combined serologic and molecular typing identified these isolates as L. interrogans serogroup Pomona serovar Kennewicki (20 strains), L. interrogans serogroup Canicola serovar Canicola (1 strain), L. borgpetersenii serogroup Sejroe serovar Hardjo (10 strains) and L. noguchii (9 strains). The latter showed remarkable phenotypic and genetic variability, belonging to 6 distinct serogroups, including 3 that did not react with a large panel of reference serogrouping antisera. Approximately 20% of cattle sampled in the field were found to be shedding pathogenic Leptospira in their urine, uncovering a threat for public health that is being largely neglected. The two L. interrogans serovars that we isolated from cattle displayed identical genetic signatures to those of human isolates that had previously been obtained from leptospirosis patients. This report of local Leptospira strains shall improve diagnostic tools and the understanding of leptospirosis epidemiology in South America. These strains could also be used as new components within bacterin vaccines to protect against the pathogenic Leptospira strains that are actually circulating, a direct measure to reduce the risk of human leptospirosis. © 2018 Zarantonelli et al. http://creativecommons.org/licenses/by/4.0/.
650 $aLEPTOSPIRA
650 $aLEPTOSPIROSIS
653 $aSALUD ANIMAL
700 1 $aSUANES, A.
700 1 $aMENY, P.
700 1 $aBURONI, F.
700 1 $aSALVARREY,X.
700 1 $aBRIANO , C.
700 1 $aASHFIELD, N.
700 1 $aSILVEIRA, C.S.
700 1 $aDUTRA, F.
700 1 $aEASTON, C.
700 1 $aFRAGA, M.
700 1 $aGIANNITTI, F.
700 1 $aHAMOND, C.
700 1 $aMACÍAS-RIOSECO, M.
700 1 $aMENÉNDEZ, C.
700 1 $aMORTOLA, A.
700 1 $aPICARDEAU, M.
773 $tPLoS Neglected Tropical Diseases, September 2018, vol. 12, Issue 9, Article number e0006694. OPEN ACCESS.
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Registro original : |
INIA La Estanzuela (LE) |
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| Registros recuperados : 14 | |
| 1. |  | RABAZA, A.; FRAGA, M.; ZARANTONELLI, L.; PÉREZ-LORENZO, C.; HIRIGOYEN, D.; GIANNITTI, F. Brote de Fiebre Q: ejemplo del rol de los bovinos como centinelas epidemiológicos. [presentación oral] En: Infectología al Día. Jornada Científico Académica de la Cátedra de Enfermedades Infecciosas, 21a., Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Ago. 12-13, 2022.| Tipo: Presentaciones Orales |
| Biblioteca(s): INIA Las Brujas. |
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| 2. | | NIEVES, C.; FERRÉS, I.; DÍAZ-VIRAQUÉ, F.; BUSCHIAZZO, A.; ZARANTONELLI, L.; IRAOLA, G. Draft genome sequences of 40 pathogenic Leptospira strains isolated from cattle in Uruguay. Microbiology Resource Announcements, 21 November 2019, Volume 8, Issue 47, Article number e00893-19. OPEN ACCESS. Doi: https://doi.org/10.1128/MRA.00893-19 Article history: Received 12 August 2019; Accepted 31 October 2019; Published 21 November 2019.
Corresponding author: Zarantonelli, L.; Laboratorio de Microbiología Molecular y Estructural, Institut Pasteur de Montevideo,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 3. | | FERRÉS, I.; CIUFFO, C.; SALAZAR, C.; ZARANTONELLI, L.; BUSCHIAZZO, A.; PICARDEAU, M.; IRAOLA, G. Evolución y genómica comparada de la espiroqueta patógena Leptospira borgpetersenii. 168. (resúmen). Áreas temáticas: Microbiología. In: Physiological Mini Reviews, 2022, volume 15, Special Issue: III (3er) Congreso Nacional de Biociencias Octubre 2022, Montevideo, Uruguay. p.186-187. Resumen publicado en las jornadas de BIOCIENCIAS: II Jornadas Binacionales Argentina-Uruguay; III Congreso Nacional 2022 "Ciencia para el desarrollo sustentable".| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 5. | | URIOSTE, V.; LOCKHART, B.; GARZÓN, J. P.; ZARANTONELLI,L.; BUCHCHIAZZO, A.; RIET-CORREA, F.; HAMOND, C.; GASTAL, G.D.A. Características uterinas y ováricas en los primeros 240 días de gestación en vaquillonas holstein naturalmente infectadas por leptospira spp. patogénicas. In: Jornadas Uruguayas de Buiatría, 48., 2021. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 31 de Mayo al 4 de Junio 2021. [Poster]. p. 248-250.| Biblioteca(s): INIA La Estanzuela. |
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| 6. | | CIUFFO, C.; ARÉVALO, A.P.; GARCIA, F.; PERDOMO, T.; CRISPO, M.; GIANNITTI, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. Estudio de la capacidad infectiva, colonización renal e inmunogenicidad de Leptospira interrogans serogrupo Pomona serovar Kennewicki en un modelo murino sub-letal y crónico. [abstract]. Sub-área 4: Patogenia, virulencia y resistencia. In: Anais III Consensos Latinoamericanos em Leptospirose Animal. Nov 30-Dic 02, 2021 (evento online).| Tipo: Abstracts/Resúmenes |
| Biblioteca(s): INIA Las Brujas. |
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| 7. | | CIUFFO, C.; ARÉVALO, A.P.; GARCIA, F.; PERDOMO, T.; CRISPO, M.; GIANNITTI, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. Estudio y caracterización de una variante autóctona de Leptospira para su potencial uso como antígeno en vacunas de uso veterinario. In: Jornadas Uruguayas de Buiatría, 49., 2022. Paysandú, Uruguay: Centro Médico Veterinario de Paysandú; Filial de la Sociedad de Medicina Veterinaria del Uruguaya; Sociedad Uruguaya de Buiatría, 9 al 11 Junio 2022. p.192-194. p.192-194.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA Las Brujas. |
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| 8. | | NIEVES. C; HAMOND, C.; BURONI, F.; RIVERO, R.; SUANES, A.; SALABERRY, X.; MACÍAS-RIOSECO, M.; SILVEIRA, C.S.; GIANNITTI, F.; RIET-CORREA, F.; BUSCHIAZZO, A.; ZARANTONELLI, L. Aplicación de métodos moleculares para la identificación y genotipicación de especies patógenas de Leptospira en muestras clínicas de bovinos. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 207-210.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 9. | | HAMOND, C.; SILVEIRA, C.S.; BURONI, F.; SUANES, A.; NIEVES, C.; SALABERRY, X.; ARÁOZ, V.; COSTA, R.A. DA; RIVERO, R.; GIANNITTI, F.; ZARANTONELLI, L. Infección aguda por Leptospira interrogans serovar kennewicki en corderos. In: Jornadas Uruguayas de Buiatría, 46., 2018, Paysandú, Uy., Matto, C.; Delpiazzo, R.(Ed.). Trabajos presentados. Paysandú: Centro Médico Veterinario de Paysandú/Sociedad Uruguaya de Buiatría, 2018. p. 186-188.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 10. | | HAMOND, C.; SILVEIRA, C.S.; BURONI, F.; SUANES, A.; NIEVES, C.; SALABERRY, X.; ARÁOZ, V.; COSTA, R.A. DA; RIVERO, R.; GIANNITTI, F.; ZARANTONELLI, L. Leptospira interrogans serogroup Pomona serovar Kennewicki infection in two sheep flocks with acute leptospirosis in Uruguay. Transboundary and Emerging Diseases ,2019 May, Vol. 66 (3), p. 1186-1194. DOI: https://doi.org/10.1111/tbed.13133 Article history: First published: 26 January 2019 /Received: 17 August 2018 / Revised: 18 January 2019 / Accepted: 19 January 2019.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 11. | | MACÍAS-RIOSECO, M.; SILVEIRA, C.S.; FRAGA, M.; CASAUX, M.L.; CABRERA, A.; FRANCIA, M.E.; REBOLLO, C.; MAYA, L.; ZARANTONELLI, L.; SUANES, A.; COLINA, R.; BUSCHIAZZO, A.; GIANNITTI, F.; RIET-CORREA, F. Causes of abortion in dairy cows in Uruguay. [Causas de aborto em bovinos de leite no Uruguai]. Pesquisa Veterinaria Brasileira, 1 May 2020, Volume 40, Issue 5, Pages 325-332. OPEN ACCESS. DOI: https://doi.org/10.1590/1678-5150-pvb-6550 Article history: Received on December 3, 2019./Accepted for publication on December 26, 2019. This research was financially supported by Agencia Nacional de Investigación e Innovación (ANII), grant FSSA_X_2014_1_105696. The authors thank...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 12. | | ZARANTONELLI, L.; SUANES, A.; MENY, P.; BURONI, F.; SALVARREY,X.; BRIANO , C.; ASHFIELD, N.; SILVEIRA, C.S.; DUTRA, F.; EASTON, C.; FRAGA, M.; GIANNITTI, F.; HAMOND, C.; MACÍAS-RIOSECO, M.; MENÉNDEZ, C.; MORTOLA, A.; PICARDEAU, M. Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis. PLoS Neglected Tropical Diseases, September 2018, vol. 12, Issue 9, Article number e0006694. OPEN ACCESS. Article History: Received: February 8, 2018; Accepted: July 16, 2018; Published: September 13, 2018.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| 13. | | GIANNITTI, F.; FRANCIA, M.E.; TANA, L.; GONZÁLEZ, F.; CABRERA, A.; CALLEROS, L.; SANGUINETTI, M.; BARCELLOS, M.; ZARANTONELLI, L.; CIUFFO, C.; MAYA, L.; CASTELLS, M.; COLINA, R.; MIRAZO, S.; SILVEIRA, C.S.; RABAZA, A.; CAFFARENA, D.; DONCEL, B.; ARÁOZ, V.; MATTO, C.; ARMENDANO, J.; SALADA, S.; SARAVIA, A.; CASAUX, M.L.; SCHILD, C.; PERDOMO, Y.; FRAGA, M.; FIERRO, S.; DORSCH, M. Causas de aborto en ovinos de Uruguay: 100 casos, 2015-2021. Producción Animal. Revista INIA Uruguay, Setiembre 2022, no.70, p.18-22. (Revista INIA; 70). Agradecimientos: A todos los productores y técnicos del SUL y actividad liberal que enviaron casos al laboratorio y a los funcionarios de INIA, Institut Pasteur de Montevideo, Udelar y DILAVE que contribuyeron con los análisis de...| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Las Brujas. |
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| 14. | | DORSCH, M.; FRANCIA, M.E.; TANA, L.R.; GONZÁLEZ, F.C.; CABRERA, A.; CALLEROS, L.; SANGUINETTI, M.; BARCELLOS, M.; ZARANTONELLI, L; CIUFFO, C.; MAYA, L.; CASTELLS, M.; MIRAZO, S.; SILVEIRA, C.S.; RABAZA, A.; CAFFARENA, D.; DONCEL, B.; ARÁOZ, V.; MATTO, C.; RMENDANO, J.I.; SALADA, S.; FRAGA, M.; FIERRO, S.; GIANNITTI, F. Diagnostic investigation of 100 cases of abortion in sheep in Uruguay: 2015-2021. Frontiers in Veterinary Science, 2022; i. 9:904786. OPEN ACCESS. Doi: https://doi.org/10.3389/fvets.2022.904786. Article history: Received: 25 March 2022/Accepted: 13 April 2022/Published: 19 May 2022.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 14 | |
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